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Publications - IBS - Institut de Biologie Structurale - Grenoble / France
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- Manual Cinétique enzymatique (Grenoble sciences) (French Edition).
- Publications - IBS - Institut de Biologie Structurale - Grenoble / France?
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Chater R. Johnson S. Louca P. Maret M. Martinez G. More B. Patterson C. Steyrer G.
Stroth U. Quasielastische Elektronstreuung. Toudic B.
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- Publications - IBS - Institut de Biologie Structurale - Grenoble / France!
Trost W. Weikard H. Anne M. Protein-Ligand Association Equilibria. Living Beings, Open Systems. Chemical Kinetics. Kinetics of Enzymatic Reactions with Michaelian Behaviour.
Experimental Methods to Study Enzymatic Reactions. Enzyme Origin and Evolution. Topology of the Active Centre of Enzymes. Formation of Enzyme-Substrate Complexes. Catalytic Mechanisms. Regulation by Non-Covalent Interactions. Regulation by Covalent Modification. Some of the recent developments in understanding the myocardial synthetic ma chinery in heart hypertrophy are also described in these papers, and we believe that the contents of this section will stimulate further research in the area of heart disease.
The second section, which mainly deals with myocardial ischemia, contains 35 chapters providing the necessary back ground for the diagnosis of ischemic heart disease and some possible ther apeutic approaches.
Publications depuis 2014
It hardly needs to be emphasized that ischemic heart disease is a major cause of death in highly industrialized countries, but unfortunately the exact mechanism by which ischemic insult leads to the development of heart cell damage is far from understood. We are hopeful that the articles in this section will provide valuable information in this field and thus will help in improving the treatment of ischemic heart disease. Bioenergetics of the cell : quantitative aspects Book 1 edition published in in English and held by 3 WorldCat member libraries worldwide.
Mitochondria are in charge of supplying the cells with energy, adjusting its functional activity under conditions of stress or other aspects of life. Mitochondria display a tissue-specific distribution. In adult rat cardiomyocytes, mitochondria are arranged regularly in a longitudinal lattice at the level of A band between the myofibrils and located within the limits of the sarcomeres. In interaction with cytoskeleton, sarcomeres and sarcoplasmic reticulum they form the functional complexes, the intracellular energetic units ICEUs.
The main role of MI is the regulation of respiration and the intracellular energy fluxes via phosophotransfer networks. The regulation of ICEUs is associated with structural proteins. The association of mitochondria with several cytoskeletal proteins described by several groups has brought to light the importance of structure-function relationship in the metabolic regulation of adult rat cardiomyocytes.
To purvey a better understanding of these findings, the present work investigated the mechanism of energy fluxes control and the role of structure-function relationship in the metabolic regulation of adult rat cardiomyocytes. To show these complex associations in adult cardiac cells several proteins were visualized by confocal microscopy: [alpha]-actinin and [beta]-tubulin isotypes.
For the first time, it was showed the existence of the specific distribution of [beta]-tubulin isotypes in adult cardiac cells. Respiratory measurements were performed to study the role of tubulins in the regulation of oxygen consumption. These results together confirmed the crucial role of cytoskeletal proteins -i. In addition, in vivo - in situ mitochondrial dynamics were studied by the transfection of GFP-[alpha]-actinin, finding that fusion phenomenon does not occur as often as it is believed in healthy adult cardiac cells.
Proceedings of the Symposium Creatine phospate : biochemistry, pharmacology and clinical efficiency : Baku, October 6, by International Society for Heart Research Book 2 editions published in in English and held by 2 WorldCat member libraries worldwide. Oxygraphy, spectrophotometry and confocal microscopy on saponin-permeabilized muscle cells or fibers were used as well as mathematic modelisation.
In muscle cells, mitochondria are ordered very precisely in 'a crystal like pattern'.
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